Alzheimer's Disease and It's Symptoms

Living With Alzheimer's Disease
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Alzheimer's disease is a progressive, degenerative disorder that attacks the brain's nerve cells, or neurons, resulting in loss of memory, thinking and language skills, and behavioral changes.

These neurons, which produce the brain chemical, or neurotransmitter, acetylcholine, break connections with other nerve cells and ultimately die. For example, short-term memory fails when Alzheimer's disease first destroys nerve cells in the hippocampus, and language skills and judgment decline when neurons die in the cerebral cortex. apgresearch.net

Early (Mild) Stage of Alzheimers Disease
-Forget words or misplaced objects
-Forget something they just read
-Ask the same question over and over
-Have increasing trouble making plans or organizing
-Not remember names when meeting new people

Middle (Moderate) Stage of Alzheimer's Disease
-Increased memory loss and confusion
-Problems recognizing family and friends
-Continuously repeating stories, favorite wants
(e.g., foods, places, songs, etc.), or motions
-Decreased ability to perform complex tasks
(e.g., planning dinner) or handle personal finances
(e.g., paying bills)
-Lack of concern for hygiene and appearance
-Requiring assistance in choosing proper clothing
to wear for day, season, or occasion

Late (Severe) Stage of Alzheimer's Disease
-Recognize faces but forget names
-Mistake a person for someone else
-Delusions—such as thinking he/she needs to go to work — may set in,
even though he/she no longer has a job
-There is a strong need for holding something close for tactile stimulation, nurturing, companionship and comfort
-Basic abilities such as eating, walking, and sitting up fade during this period; the individual may no longer recognize when he is thirsty or hungry and will need help with all basic activities of daily living. apgresearch.net

Contact APG Clinical Research today to see if you can qualify for one of our clinical studies involving Alzheimer's.

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Clinical Research for Bipolar Disorder

Taking Part in a Clinical Research Study for Manic or Mixed Bipolar Disorder
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Manic or Mixed Bipolar I Disorder
One of the most easily diagnosed forms of Bipolar disorder is Bipolar I. Noted for the presence of pronounced elevated mood, called mania, a person with Bipolar I has both episodes of mania and depression. apgresearch.net

Symptoms of Mania
Categorized as a profound mood disturbance of elation, irritability, or expansiveness, a manic episode can drastically impair a person’s social and occupational functioning, and can also lead to hospitalization. Symptoms of a manic episode may include grandiosity, diminished need for sleep, excessive talking, or racing thoughts, among others. apgresearch.net

Symptoms of Bipolar I Depression
Bipolar I includes the presence of depressive episodes, which can be characterized by depressed mood, or a loss of pleasure. Experiencing a depressive episode can impair one’s ability to function normally, and cause a huge amount of distress. Some symptoms of a depressive episode may include significant weight loss or gain, hypersomnia or insomnia, and loss of energy, among others.  A Bipolar I disorder episode could be diagnosed as both manic and depressive.  apgresearch.net

Volunteering for a clinical trial is one way to help in understanding and treating. Studies need participants of different ages, sexes, races, and ethnicity to ensure that results are meaningful for many people.
What is the study for: Bipolar I disorder
Ages: 10-17 years old
- Must have a primary diagnosis of Bipolar I disorder
- Must stop medications prior to starting study
How long: 8-10 months
Frequency of visits: Weekly for 15 weeks, then monthly
Medication: N/A
For cases involving patients 18 years or older we recommend the use of Equetro- FDA Approved for Adults
If you qualify to participate in a study, you will receive:
- Assessments by a Board Certified Psychiatrist
- Investigational medication at no cost
- Study-related care and monitoring
- Compensation for time and travel
APG Research provides extensive service to our sponsors, physicians and research patients. Our team has a combined 40 years of clinical research experience in adult and pediatric studies including Major Depression, Autism, Anxiety, Bipolar, OCD, ADHD and Schizophrenic Disorders.

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An Autism Study for Children

See If Your Child Can Be A Part Of An Autism Study
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Each child with autism is unique and, so, each autism intervention plan should be tailored to address specific needs.

Intervention can involve behavioral treatments, medicines or both. Many persons with autism have additional medical conditions such as sleep disturbance, seizures and gastrointestinal (GI) distress. Addressing these conditions can improve attention, learning and related behaviors. apgresearch.net

Early intensive behavioral intervention involves a child's entire family, working closely with a team of professionals. In some early intervention programs, therapists may come into the home to deliver services. This can include parent training with the parent leading therapy sessions under the supervision of the therapist. Other programs deliver therapy in a specialized center, classroom or preschool. apgresearch.net

Typically, different interventions and supports become appropriate as a child develops and acquires social and learning skills. As children with autism enter school, for example, they may benefit from targeted social skills training and specialized approaches to teaching.

Contact APG Clinical Research today to see if your child can qualify for one of our clinical studies involving Autism.

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Living with Refractory Schizophrenia

What is Refractory Schizophrenia?
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Schizophrenia is a complex, chronic mental health disorder characterized by an array of symptoms, including delusions, hallucinations, disorganized speech or behavior, and impaired cognitive ability. Typically when two or three treatments with typical or atypical antipsychotic drugs are unsuccessful a patient's schizophrenia is considered refractory. There’s an estimated 30% of people whose schizophrenia is diagnosed as refractory. Decades after the introduction of antipsychotic medication, schizophrenia continues to be among the most severe psychiatric illnesses. It is widely accepted, however, that the illness arises from multiple factors, including genetic susceptibility and environmental influences. apgresearch.net

When someone has schizophrenia it’s important to have a healthy support system coming from a variety of sources including, family, friends, and doctors, among others.  Utilizing additional resources as well as recognizing when there’s a need to ask for help will be key when it comes to dealing with the symptoms of schizophrenia. With this disease being so complex, and the strides for medication being less than optimal, now is the time to participate in clinical research. apgresearch.net

What is the study for: Refectory Schizophrenia
Ages: 18-25 years old
- Must have diagnosis of Schizophrenia that is clinically stable with residual symptoms
- No medication changes within 8 weeks
- Must be taking Clozapine
How long: 13 weeks
Frequency of visits: Every 2 weeks
Medication: Sodium Benzoate
If you qualify to participate in a study, you will receive:
- Assessments by a Board Certified Psychiatrist
- Investigational medication at no cost
- Study-related care and monitoring
- Compensation for time and travel
APG Research provides extensive service to our sponsors, physicians and research patients. Our team has a combined 40 years of clinical research experience in adult and pediatric studies including Major Depression, Autism, Anxiety, Bipolar, OCD, ADHD and Schizophrenic Disorders.

Call today to see if your child would benefit from participating in one our studies.

apgresearch.net | 407-423-7149 | plus.google.com/+APGresearchNet
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Dealing With Alzheimer's

Have you or someone you know been diagnosed with Alzheimer’s. If yes you may be eligible to participate in the studies. apgresearch.net | 407-423-7149

Most people have late- onset Alzheimer’s, in which symptoms for the disease become apparent in a person’s mid- 60’s. Research suggest that there are factors beyond genetics that may play a role in development of Alzheimer’s disease. Vascular conditions such as heart disease and stroke correlate to cognitive decline. As well as metabolic conditions such as diabetes, these conditions and their relationship to Alzheimer’s is continuously being researched with clinical trials.
Participants in Alzheimer's clinical research help scientists learn how the brain changes with healthy aging and with Alzheimer’s. The clinical studies are testing ways to understand, diagnose, treat, and prevent Alzheimer's disease. Volunteering for a clinical trial is one way to help in the fight against Alzheimer's disease. Studies need participants of different ages, sexes, races, and ethnicities to ensure that results are meaningful for many people. apgresearch.net

What is the study for: Alzheimer’s/ MCI
Ages: 50-85 years old
- Must be positive for brain amyloid
- If taking Memantine or AChEl, must be on a stable dose for 12 weeks
- Must have a caregiver willing to participate until the end of the study
How long: 2.5 years
Frequency of visits: Every two weeks for the first three months, then monthly
Medication: E2609

If you qualify to participate in a study, you will receive:
- Assessments by a Board Certified Psychiatrist
- Investigational medication at no cost
- Study-related care and monitoring
- Compensation for time and travel

APG Research provides extensive service to our sponsors, physicians and research patients. Our team has a combined 40 years of clinical research experience in adult and pediatric studies including Major Depression, Autism, Anxiety, Bipolar, OCD, ADHD and Schizophrenic Disorders. apgresearch.net

Call today to see if you or someone you know would benefit from participating in one our studies.

apgresearch.net | 407-423-7149 | plus.google.com/+APGresearchNet

Are You Suffering From Major Depressive Disorder?

In the United States it is reported that upwards of 70% of patients with Major Depressive Disorder (MDD) are partial or non-responders to the first- line therapies which include SSRIs and SNRIs.

Designation FOR Adjunctive Treatment of Major Depressive Disorder (MDD), has a mechanism of action which is entire different from that of atypical antipsychotics. The drug, rapastinel, is an N-methyl-D-aspartate receptor (NMDAR) modulator with a novel and complete pharmacological mechanism of action, acting as a nonselective agent at NR2 subunits and displaying properties as a functional partial agonist in a number of pharmacological assays. apgresearch.net

At APG Clinical Research, we are conducing more research into this new drug, and invite you to refer people who meet the following criteria:
- Ages 18 and up
- With a current major depressive episode in the last 8 weeks and not exceeding 18 months in duration
- And, have no more than partial response (<50% improvement) to ongoing treatment with a protocol- allowed antidepressant

APG Research provides extensive service to our sponsors, physicians and research patients. Our team has a combined 40 years of clinical research experience in adult and pediatric studies including Major Depression, Autism, Anxiety, Bipolar, OCD, ADHD and Schizophrenic Disorders. apgresearch.net

Call today to see if your child would benefit from participating in one our studies.

apgresearch.net | 407-423-7149 | plus.google.com/+APGresearchNet

Schizophrenia in Adolescents

The psychotic disorder Schizophrenia is typically begins in late adolescence into early adulthood. The shorthand term ‘adolescent-onset’ typically refers to the onset of Schizophrenia in child and adolescent cases up to the age of 17, with the onset being exceedingly rare in cases under 10 years old.

What is Schizophrenia?
Schizophrenia is linked to structural and functional abnormalities in the regions of the brain that control coordinated thinking, perceptions, and behaviors. People who have Schizophrenia will often find it difficult to filter and process information correctly. This can often cause delusions and hallucinations that cause the afflicted persons to have a mental break from reality. Other symptoms of Schizophrenia can include disorganized thinking or speech, abnormal motor behaviors, or other negative symptoms. Negative symptoms refer to the absence of something that is typically present. This can refer to decreased emotional expression, diminished involvement in activities, or loss of speech or social interaction. While Schizophrenia usually develops over the course of several year, negative symptoms will often appear a few years before any other symptoms emerge.  

What You Can Do to Help
Volunteering for a clinical trial is one way to help in understanding and treating. Studies need participants of different ages, sexes, races, and ethnicities to ensure that results are meaningful for many people.
What is the study for: Adolescent Schizophrenia
Ages: 12-17 years old
- Must have diagnosis of Schizophrenia that is clinically stable with residual symptoms
- No medication changes within 8 weeks
How long: 10 weeks
Frequency of visits: Every 2 weeks
Medication: Sodium Benzoate
If you qualify to participate in a study, you will receive:
- Assessments by a Board Certified Psychiatrist
- Investigational medication at no cost
- Study-related care and monitoring
- Compensation for time and travel
APG Research provides extensive service to our sponsors, physicians and research patients. Our team has a combined 40 years of clinical research experience in adult and pediatric studies including Major Depression, Autism, Anxiety, Bipolar, OCD, ADHD and Schizophrenic Disorders.

Contact APG Clinical Research today to see if your child can qualify for one of our clinical studies involving Schizophrenia.

apgresearch.net | 407-423-7149 | plus.google.com/+APGresearchNet